Abstract
The 2016 National Action Plan aims for reduction in antimicrobial resistance (AMR)
to tetracyclines, third-generation cephalosporins, and fluoroquinolones in Escherichia coli isolates from livestock: to lower the tetracycline resistance of E. coli to 33% or less; to maintain the third-generation cephalosporin resistance of E. coli at the same level as in the other G7 countries as of 2020; and to maintain the fluoroquinolone
resistance of E. coli at the same level as in the other G7 countries as of 2020. A relatively unexplored
facet of reducing AMR is the impact of minimizing transmission of AMR strains by companion
animals. In this study we compared AMR rates in Staphylococcus intermedius group (SIG) and E. coli isolated from diseased companion animals in an animal hospital before and after restriction
of antimicrobial use. Our study spanned a 4.5-year period from 2014 to June 2018 during
which antimicrobial use was restricted in 2016. During this period, abundance of methicillin-resistant
SIG isolates from the hospital dropped from 41.5% to 9.3%, and that of extended-spectrum
β-lactamase (ESBL)-producing E. coli isolates dropped from 29.5% to 9.5%. Tests for antimicrobial susceptibility revealed
significantly reduced rates of AMR to enrofloxacin and levofloxacin in SIG isolates,
and to cefazolin in E. coli isolates after antimicrobial use was restricted. Our observations suggest that restriction
of antimicrobial use, especially that of third-generation cephalosporins and fluoroquinolones,
is an effective method for reducing AMR rates. These findings will be relevant in
guiding antimicrobial restriction approaches in other animal hospitals and clinics.
Keywords
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Article info
Publication history
Published online: March 21, 2019
Accepted:
February 22,
2019
Received in revised form:
February 18,
2019
Received:
November 16,
2018
Footnotes
☆Authorship statement: All authors meet the ICMJE authorship criteria.
Identification
Copyright
© 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
