Abstract
Inhaled liposomal antimicrobials are known to cause hypersensitivity pneumonitis.
Amikacin liposome inhalation suspension (ALIS) is a promising novel antimicrobial
agent against refractory Mycobacterium avium complex infections. The frequency of drug-induced lung injury caused by ALIS is relatively
high. To date, no reports of ALIS-induced organizing pneumonia diagnosed by bronchoscopy
are available.
We report a case of a 74-year-old female patient presenting with non-tuberculous mycobacterial
pulmonary disease (NTM-PD). She was treated with ALIS for refractory NTM-PD. Fifty-nine
days after starting ALIS, the patient developed a cough, and her chest radiographs
indicated deterioration. She was diagnosed with organizing pneumonia based on pathological
findings of the lung tissues obtained by bronchoscopy. After switching from ALIS to
amikacin infusion, her organizing pneumonia improved. It is difficult to distinguish
between organizing pneumonia and an exacerbation of NTM-PD based on chest radiography
alone. Therefore, it is essential to perform an active bronchoscopy for diagnosis.
Keywords
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Article info
Publication history
Published online: April 24, 2023
Accepted:
April 19,
2023
Received in revised form:
March 30,
2023
Received:
December 13,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
