Abstract
Fungal otitis externa is a disease encountered occasionally and is caused mostly by
Aspergillus or Candida spp. We report a woman with fungal otitis externa who also had typical findings in
the external auditory canal. The results of a culture showed coinfection with Candida auris and Aspergillus flavus. Identification of both species was performed by sequencing analysis of the 26S rDNA
(D1/D2) and β-tubulin regions. Additionally, the newly developed CHROMagar™ Candida
Plus medium was a useful tool for the easy and rapid identification of C. auris. To the best of our knowledge, this is the first report of fungal otitis externa
caused by coinfection with C. auris and A. flavus. This case showed good susceptibility to many antifungal drugs and fortunately had
a good clinical course with 1% bifonazole cream, which was applied to the fungal coinfection.
Notably, C. auris is a multidrug-resistant yeast-like fungus. The increase in drug-resistant fungi
and co-infections caused by these pathogens can make the diagnosis and treatment more
complex and difficult. To solve these problems, performing rapid and accurate identification
and susceptibility testing using chromogenic medium and molecular biological analysis
would be useful.
Keywords
Abbreviations:
CCP (CHROMagar™ Candida Plus), CDC (Centers for Disease Control and Prevention), MIC (minimum inhibitory concentration)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 01, 2023
Accepted:
April 19,
2023
Received in revised form:
March 27,
2023
Received:
February 7,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
