Abstract
Bacteria of the Mycobacterium avium complex, which are environmental organisms found in soil and water, have been found
to cause human lung diseases. Although infection is reported to occur in cohabiting
patients, the incidence of infection from the single clone remains rarely documented.
Herein, we report a case of M. avium lung disease caused by specimens with the same clone strains in a married couple.
The wife, a 67-year-old female, had severe M. avium lung disease despite receiving multidrug chemotherapy for eleven years. The husband,
a 68-year-old male, died of acute lung injury complicated by M. avium pleurisy. The result of the variable-number tandem-repeat analysis of isolates from
serial sputum specimens of both patients indicated that the severe M. avium lung disease in a married couple was caused by the isolates with identical pattern.
This case were considered to have acquired clarithromycin resistance during each clinical
course, revealing the possibility of infection with a strain that may induce severe
pulmonary condition.
Keywords
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Article info
Publication history
Published online: May 16, 2023
Accepted:
April 19,
2023
Received in revised form:
April 6,
2023
Received:
February 18,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
